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Mechanisms for oxidizing low-density lipoprotein - Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

被引：76
作者：
Gaut, JP
Heinecke, JW
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 3-4期
关键词：
D O I：
10.1016/S1050-1738(01)00101-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed. (C) 2001, Elsevier Science Inc.
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页码：103 / 112
页数：10
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