Overexpression of the PDCD2-like gene results in Inhibited TNF-α production in activated Daudi cells

被引：5

作者：

Chen, Q. ^{[2
]}

Yan, C. -Q. ^{[1
]}

Liu, F. -J. ^{[2
]}

Tong, J. ^{[2
]}

Miao, S. -L. ^{[2
]}

Chen, J. -P. ^{[1
]}

机构：

[1] Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Hangzhou 310021, Peoples R China

[2] Soochow Univ, Sch Radiol & Publ Hlth, Suzhou 215123, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2008年 / 69卷 / 4-5期

关键词：

PDCD2-like; TNF-alpha; PDCD2; anti-inflammation;

D O I：

10.1016/j.humimm.2008.01.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are stilt unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a rote in inflammation. In Daudi cells exposed to Lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 was downregulated. Overexpression of PDCD2-like gene effectively attenuated tumor necrosis factor (TNF)-alpha release but elevated interteukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS). It is possible that both proteins have anti-inflammatory effects Like IL-6. The results have implications for understanding the function of PDCD2/PDCD2-like proteins and may help in the development of novel anti-inflammatory drugs. (C) 2008 American Society for Histocompatibitity and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：259 / 265

页数：7

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