Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia

被引：15

作者：

Aishima, Shinichi ^{[1
,2
]}

Nishihara, Yunosuke ^{[2
]}

Tsujita, Eiji ^{[3
]}

Taguchi, Kenichi ^{[4
]}

Soejima, Yuji ^{[3
]}

Taketomi, Akinobu ^{[3
]}

Ikeda, Yasuharu ^{[5
]}

Maehara, Yoshihiko ^{[3
]}

Tsuneyoshi, Masazumi ^{[2
]}

机构：

[1] Hamanoumachi Hosp, Dept Pathol, Chuo Ku, Fukuoka 8108539, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka 8128582, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 8128582, Japan

[4] Kyushu Natl Canc Ctr, Inst Clin Res, Fukuoka 8111395, Japan

[5] Fukuoka City Hosp, Dept Surg, Fukuoka 8120046, Japan

来源：

HUMAN PATHOLOGY | 2008年 / 39卷 / 06期

关键词：

liver cirrhosis; biliary neoplasia; immunohistochemistry;

D O I：

10.1016/j.humpath.2007.10.031

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

We describe the histopathologic features of 2 cases of biliary neoplasia, with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin gamma 2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia, with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia. (C) 2008 Published by Elsevier Inc.

引用

页码：939 / 947

页数：9

共 23 条

[1]

Superficially spreading cholangiocarcinoma [J].