Studies on penam sulfones .3. Synthesis and beta-lactamase inhibitory activity of sodium (6R)-6-(alpha-hydroxybenzyl)-2 beta-methoxyiminomethyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1-dioxide and sodium 2 beta-acyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1-dioxide

被引：9

作者：

Czajkowski, DP

Reddy, AVN

Setti, EL

Phillips, OA

Micetich, RG

Kunugita, C

Maiti, SN

机构：

[1] SYNPHAR LABS INC,TAIHO ALBERTA CTR,EDMONTON,AB T6E 5V2,CANADA

[2] TAIHO PHARMACEUT CO LTD,TOKUSHIMA RES INST,TOKUSHIMA 77101,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(96)00575-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and in vitro synergies of (6R)-6-(alpha-hydroxybenzyl)-2 beta-methoxyiminomethyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1-dioxide (4) and 2 beta-acyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：11 / 14

页数：4

共 8 条

[1] SUBSTITUTED PENICILLANIC ACID 1,1-DIOXIDES AS BETA-LACTAM INHIBITORS - STUDIES ON 6-BENZYLIDENEPENAM AND HYDROXYBENZYLPENAM SULFONES [J].