Th2 cytokines and asthma - The role of interleukin-5 in allergic eosinophilic disease

被引：198

作者：

Greenfeder, S ^{[1
]}

Umland, SP ^{[1
]}

Cuss, FM ^{[1
]}

Chapman, RW ^{[1
]}

Egan, RW ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Dept Allergy, Kenilworth, NJ 07033 USA

来源：

RESPIRATORY RESEARCH | 2001年 / 2卷 / 02期

关键词：

allergy; asthma; eosinophil; interleukin-5;

D O I：

10.1186/rr41

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.

引用

页码：71 / 79

页数：9

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