Derive and conquer: sourcing and differentiating stem cells for therapeutic applications

被引：109

作者：

Klimanskaya, Irina ^{[1
]}

Rosenthal, Nadia ^{[2
]}

Lanza, Robert ^{[1
]}

机构：

[1] Adv Cell Technol, Worcester, MA 01605 USA

[2] European Mol Biol Lab, Mouse Biol Unit, Rome, Italy

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrd2403

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Although great progress has been made in the isolation and culture of stem cells, the future of stem-cell-based therapies and their productive use in drug discovery and regenerative medicine depends on two key factors: finding reliable sources of multipotent and pluripotent cells and the ability to control their differentiation to generate desired derivatives. It is essential for clinical applications to establish reliable sources of pathogen-free human embryonic stem cells (ESCs) and develop suitable differentiation techniques. Here, we address some of the problems associated with the sourcing of human ESCs and discuss the current status of stem-cell differentiation technology.

引用

页码：131 / 142

页数：12

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