Synthesis of novel piperazine based building blocks: 3,7,9-triazabicyclo[3.3.1]nonane, 3,6,8-triazabicyclo[3.2.2]-nonane, 3-oxa-7,9-diazabicyclo[3.3.1]nonane and 3-oxa-6,8-diazabicyclo[3.2.2]nonane

被引：30

作者：

Revesz, L ^{[1
]}

Blum, E ^{[1
]}

Wicki, R ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 33期

关键词：

bridged piperazines;

D O I：

10.1016/j.tetlet.2005.06.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The preparation of four novel bridged piperazine building blocks is described: 3,7,9-triazabicyclo[3.3.1]nonane 1, 3-oxa-7,9-diazabicyclo[3.3.1]nonane 2, 3,6,8-triazabicyclo[3.2.2]nonane 3 and 3-oxa-6,8-diazabicyclo[3.2.2]nonane 4. The scaffold of 1 was synthesized from N,N'-dibromobenzenesulfonamide and ethyl acrylate. Compound 2 may be prepared from identical starting materials or alternatively from alpha,alpha'-diglycerol. Compounds 3 and 4 were identified as side products from possible aziridinium intermediates. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：5577 / 5580

页数：4

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