Prolactin release during exercise in normal and adrenodemedullated untrained rats submitted to central cholinergic blockade with atropine

被引:22
作者
Lima, NRV [1 ]
Pereira, W
Reis, AM
Coimbra, CC
Marubayashi, U
机构
[1] Univ Fed Minas Gerais, Sch Phys Educ, Lab Physiol Exercise, BR-31270901 Belo Horizonte, MG, Brazil
[2] Frederal Univ, Inst Biol Sci, Dept Physiol & Biophys, BR-30127091 Belo Horizonte, MG, Brazil
关键词
D O I
10.1006/hbeh.2001.1727
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
To study the role of the central cholinergic system in pituitary prolactin (PRL) release during exercise we injected atropine (5 x 10(-7) mol) into the lateral cerebral ventricle of intact or adrenodemedullated (ADM) untrained rats, at rest or submitted to exercise on a treadmill (18 m . min(-1), 5% grade) until exhaustion. The rats were implanted with chronic jugular catheters for blood sampling and with unilateral intracerebroventricular (icv) cannulas placed in the right lateral ventricle. Blood prolactin concentrations were measured before and every 10 min after the start of exercise for a period of 60 min. After the animals started running, plasma prolactin levels rose rapidly in both normal and ADM rats, reaching near maximum at 10 min. Close to exhaustion (19.8 +/- 2.9 min for intact rats and 23.5 +/- 4.1 min for ADM) they were still high, remained increased until 30 min, and returned to preexercise levels at 40 min. lcv injections of atropine decreased the time to exhaustion by 67% in intact rats and by 96.2% in ADM and also reduced the exercise-induced PRL release in both intact (50%) and ADM rats (90%). The results showed that prolactin release induced by exercise was dependent on the exercise workload and could be observed as early as after 10 min of running, remaining increased until 30 min. These data indicate that adrenodemedullation does not affect prolactin secretion induced by exercise, although adrenodemedullated rats proved to be more sensitive to the reducing effect of central cholinergic blockade on their maximal capacity for exercise. (C) 2001 Elsevier Science.
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页码:526 / 532
页数:7
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