Expression of Tcf/Lef and sFrp and localization of β-catenin in the developing mouse lung

被引：64

作者：

Tebar, M

Destrée, O

de Vree, WJA

Ten Have-Opbroek, AAW

机构：

[1] Leiden Univ, Med Ctr, Dept Pulmonol, NL-2300 RC Leiden, Netherlands

[2] Netherlands Inst Dev Biol, NL-3584 CT Utrecht, Netherlands

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 109卷 / 02期

关键词：

beta-catenin; Tcf1; Lef1; Tcf-3; Tcf4; sFrp1; sFrp2; sFrp3; sFrp4; surfactant protein A; whole-mount in situ hybridization immunohistochemistry; mouse; embryonic; lung; primordial; alveolar; epithelium; type-II cells; mesenchyme; differentiation; prenatal; Wnt signaling; spatial; temporal;

D O I：

10.1016/S0925-4773(01)00556-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent evidence that Writs and other genes in the Writ signaling pathway are expressed in embryonic and adult mouse lung suggests that this pathway is important for cell fate decisions and differentiation of lung cell types. We therefore examined the expression and protein distribution of several Writ pathway components during prenatal mouse lung development using whole-mount in situ hybridization and immunohistochemistry. Between embryonic days 10,5 and 17.5 (E10.5-E17.5). beta -catenin was localized in the cytoplasm. and often also the nucleus, of the undifferentiated primordial epithelium (PE), differentiating alveolar epithelium (AE; present from E14.5 onward), and adjacent mesenchyme. Tcf1, Lef1, Tcf3, Tcf4, sFrp1. sFrp2 and sFrp4 were also expressed in the PE, AE, and adjacent mesenchyme in specific spat io-temporal patterns. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：437 / 440

页数：4

共 12 条

[1] Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin [J].