Reduced bone density at completion of chemotherapy for a malignancy

被引:55
作者
Arikoski, P
Komulainen, J
Riikonen, P
Jurvelin, JS
Voutilainen, R
Kröger, H
机构
[1] Kuopio Univ Hosp, Dept Pediat, FIN-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, Dept Clin Physiol, FIN-70211 Kuopio, Finland
[3] Kuopio Univ Hosp, Dept Surg, FIN-70211 Kuopio, Finland
关键词
bone mineral density; malignancy; osteopenia;
D O I
10.1136/adc.80.2.143
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objectives-Osteoporosis and pathological fractures occur occasionally in children with malignancies. This study was performed to determine the degree of osteopenia in children with a malignancy at completion of chemotherapy. Methods-Lumbar spine (L2-L4) bone mineral density (BMD; g/cm(2)) and femoral neck BMD were measured by dual energy x ray absorptiometry in 22 children with acute lymphoblastic leukaemia (ALL), and in 26 children with other malignancies. Apparent volumetric density was calculated to minimise the effect of bone size on BMD. Results were compared with those of 113 healthy controls and expressed as age and sex standardised mean Z scores. Results-Patients with ALL had significantly reduced lumbar volumetric (-0.77) and femoral areal and volumetric BMDs (-1.02 and -0.98, respectively). In patients with other malignancies, femoral areal and apparent volumetric BMDs were significantly decreased (-0.70 and -0.78, respectively). Conclusions-The results demonstrate that children with a malignancy are at risk of developing osteopenia. A follow up of BMD after the completion of chemotherapy should facilitate the identification of patients who might be left with impaired development of peak bone mass, and who require specific interventions to prevent any further decrease in their skeletal mass and to preserve their BMD.
引用
收藏
页码:143 / 148
页数:6
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