Fluoroquinolone susceptibilities of efflux-mediated multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia

被引:48
作者
Zhang, L [1 ]
Li, XZ [1 ]
Poole, K [1 ]
机构
[1] Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada
关键词
D O I
10.1093/jac/48.4.549
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The antibacterial activities of seven fluoroquinolones (ciprofloxacin, BAYy3118, clinafloxacin, gemifloxacin, moxifloxacin, sparfloxacin and trovafloxacin) against isogenic efflux-mediated multidrug-resistant strains of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia, were compared. The results indicate that these fluoroquinolones are all substrates for the multidrug eff lux systems of these organisms. Clinafloxacin was found generally to be the most active agent against multidrug-resistant strains.
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页码:549 / 552
页数:4
相关论文
共 10 条
[1]  
BURNS JL, 1996, ANTIMICROBIAL AGENTS, V40, P304
[2]   Mechanisms of action and resistance of older and newer fluoroquinolones [J].
Hooper, DC .
CLINICAL INFECTIOUS DISEASES, 2000, 31 :S24-S28
[3]  
Li XZ, 1998, ANTIMICROB AGENTS CH, V42, P399
[4]   Influence of the MexA-MexB-OprM multidrug efflux system on expression of the MexC-MexD-OprJ and MexE-MexF-OprN multidrug efflux systems in Pseudomonas aeruginosa [J].
Li, XZ ;
Barré, N ;
Poole, K .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (06) :885-893
[5]  
LI XZ, 2000, 100 GEN M AM SOC MIC, P8
[6]   Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa:: Novel agents for combination therapy [J].
Lomovskaya, O ;
Warren, MS ;
Lee, A ;
Galazzo, J ;
Fronko, R ;
Lee, M ;
Blais, J ;
Cho, D ;
Chamberland, S ;
Renau, T ;
Leger, R ;
Hecker, S ;
Watkins, W ;
Hoshino, K ;
Ishida, H ;
Lee, VJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) :105-116
[7]   Antibiotic resistance caused by gram-negative multidrug efflux pumps [J].
Nikaido, H .
CLINICAL INFECTIOUS DISEASES, 1998, 27 :S32-S41
[8]   Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria [J].
Poole, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2233-2241
[9]   Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa [J].
Srikumar, R ;
Li, XZ ;
Poole, K .
JOURNAL OF BACTERIOLOGY, 1997, 179 (24) :7875-7881
[10]   Multiple antibiotic resistance in Stenotrophomonas maltophilia:: Involvement of a multidrug efflux system [J].
Zhang, L ;
Li, XZ ;
Poole, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :287-293