Effects of rTMS on grip force control following subcortical stroke

被引：100

作者：

Dafotakis, Manuel ^{[1
,2
,3
]}

Grefkes, Christian ^{[1
,2
,3
]}

Eickhoff, Simon B. ^{[2
]}

Karbe, Hans ^{[4
]}

Fink, Gereon R. ^{[1
,2
,3
]}

Nowak, Dennis A. ^{[1
,2
,3
]}

机构：

[1] Univ Cologne, Univ Hosp Cologne, Dept Neurol, D-50924 Cologne, Germany

[2] Res Ctr Julich, Inst Neurosci & Biophys, Julich, Germany

[3] Res Ctr Julich, BICW, Julich, Germany

[4] Neurol Rehabil Ctr Godeshohe, Bonn, Germany

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 211卷 / 02期

关键词：

interhemispheric competition model; transcranial magnetic brain stimulation; dexterity; stroke rehabilitation;

D O I：

10.1016/j.expneurol.2008.02.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Within the concept of interhemispheric competition we tested the effect of inhibitory 1 Hz repetitive transcranial magnetic stimulation (rTMS), applied over the primary motor cortex of the unaffected hemisphere, upon dexterity of the affected hand in subcortical stroke patients. Subjects grasped, lifted and held an instrumented object between the index finger and thumb with both the affected and unaffected hand prior to (baseline) and following 1 Hz rTMS applied over (i) the vertex (control stimulation) and (ii) the primary motor cortex of the unaffected hemisphere. Compared to baseline, I Hz rTMS applied over the unaffected primary motor cortex, but not the vertex, improved the efficiency and timing of grasping and lifting with the affected hand. Our data support the interhemispheric competition concept and furthermore reinforce current efforts to implement rTMS in novel approaches to stroke rehabilitation. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：407 / 412

页数：6

共 49 条

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