Macromolecular organization of basement membranes

被引：520

作者：

Timpl, R

机构：

[1] Department of Protein Chemistry, Max-Ranck-Institut für Biochemie

来源：

CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(96)80102-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A considerable variety of basement membrane components, including in particular more than ten laminin isoforms and their novel alpha chains (alpha 3, alpha 4 and alpha 5), has been characterized in recent studies. The functional properties of these components are increasingly being analyzed by recombinant technologies and by structural studies at atomic resolution, techniques which led to the elucidation of the nidogen-binding epitope on the laminin gamma 1 chain. Novel insights into functions of basement membrane components have been obtained from gene-targeting experiments and studies of mutated genes identified in inherited disorders.

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收藏

页码：618 / 624

页数：7

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