The role of lipid droplets in metabolic disease in rodents and humans

被引：646

作者：

Greenberg, Andrew S. ^{[1
]}

Coleman, Rosalind A. ^{[2
]}

Kraemer, Fredric B. ^{[3
,4
]}

McManaman, James L. ^{[5
]}

Obin, Martin S. ^{[1
]}

Puri, Vishwajeet ^{[6
]}

Yan, Qing-Wu ^{[1
]}

Miyoshi, Hideaki ^{[7
]}

Mashek, Douglas G. ^{[8
]}

机构：

[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Obes & Metab Lab, Boston, MA 02111 USA

[2] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA

[3] Stanford Univ, Div Endocrinol, Palo Alto, CA 94304 USA

[4] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA

[5] Univ Colorado, Dept Obstet & Gynecol, Div Reprod Sci, Denver, CO 80202 USA

[6] Boston Univ, Sch Med, Dept Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA

[7] Hokkaido Univ, Grad Sch Med, Dept Internal Med 2, Sapporo, Hokkaido, Japan

[8] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 06期

关键词：

DIFFERENTIATION-RELATED PROTEIN; ADIPOSE TRIGLYCERIDE LIPASE; HORMONE-SENSITIVE LIPASE; FAT-SPECIFIC PROTEIN-27; NECROSIS-FACTOR-ALPHA; MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; ADIPOCYTE LIPOLYSIS; HEPATIC STEATOSIS;

D O I：

10.1172/JCI46069

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

引用

页码：2102 / 2110

页数：9

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