No linkage or association of the nitric oxide synthase genes to multiple sclerosis

被引：14

作者：

Modin, H

Dai, Y

Masterman, T

Svejgaard, A

Sorensen, PS

Oturai, A

Ryder, LP

Spurkland, A

Vartdal, F

Laaksonen, M

Sandberg-Wollheim, M

Myhr, KM

Nyland, H

Hillert, J

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-12186 Huddinge, Sweden

[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Rigshosp, Dept Neurol, Copenhagen, Denmark

[4] Univ Oslo, Rikshosp, Natl Hosp, Inst Immunol, N-0027 Oslo, Norway

[5] Univ Turku, Turku Immunol Ctr, Turku, Finland

[6] Univ Turku, Dept Virol, Turku, Finland

[7] Dept Neurol, Lund, Sweden

[8] Haukeland Univ Hosp, Dept Neurol, N-5021 Bergen, Norway

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 01期

关键词：

multiple sclerosis; nitric oxide (NO); neuroimmunology; neurogenetics;

D O I：

10.1016/S0165-5728(01)00366-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown etiology. Nitric oxide (NO) is a free radical that participates in a variety of biological processes. It is an important mediator in the immune response. Several studies indicate involvement of NO in the pathogenesis of MS. We studied five markers within the three NO synthase genes with regards to susceptibility and disease course in 156 affected sib-pairs and in 96 "benign" and 96 "severe" definite MS patients and 148 controls. We found no significant association or evidence for linkage in our data sets. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：95 / 100

页数：6

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