Maintenance and regulation of DNA methylation patterns in mammals

被引：66

作者：

Chen, ZX

Riggs, AD ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Div Biol, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Duarte, CA 91010 USA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2005年 / 83卷 / 04期

关键词：

epigenetics; epigenetic fidelity; DNA methyltransferase; DNA demethylase; gene regulation;

D O I：

10.1139/O05-138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proper establishment and faithful maintenance of epigenetic information is crucial for the correct development of complex organisms. For mammals, it is now accepted that DNA methylation is an important mechanism for establishing stable heritable epigenetic marks. The distribution of methylation in the genome is not random, and patterns of methylated and unmethylated DNA are well regulated during normal development. The molecular mechanisms by which methylation patterns are established and maintained are complex and just beginning to be understood. In this review, we summarize recent progress in understanding the regulation of mammalian DNA methylation patterns, with an emphasis on the emerging roles of several protein and possible RNA factors. We also revisit the stochastic model of maintenance methylation and discuss its implications for epigenetic fidelity and gene regulation.

引用

页码：438 / 448

页数：11

共 123 条

[1] Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family [J].