Y-box-binding protein 1 (YB-1) and its functions

被引：384

作者：

Eliseeva, I. A. ^{[1
]}

Kim, E. R. ^{[1
]}

Guryanov, S. G. ^{[1
]}

Ovchinnikov, L. P. ^{[1
]}

Lyabin, D. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Prot Res, Pushchino 142290, Moscow Region, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2011年 / 76卷 / 13期

基金：

俄罗斯基础研究基金会;

关键词：

YB-1; Y-box binding proteins; regulation of gene expression; DNA repair; transcription; translation; oncogenesis; oncomarker; multidrug resistance; metastasis; COLD-SHOCK DOMAIN; TRANSCRIPTION FACTOR YB-1; MESSENGER-RIBONUCLEOPROTEIN PARTICLES; TOPOISOMERASE-II-ALPHA; INCREASED NUCLEAR-LOCALIZATION; STAGE EMBRYONIC-DEVELOPMENT; AP-ENDONUCLEASE APE1/REF-1; P-GLYCOPROTEIN EXPRESSION; GROWTH-FACTOR RECEPTOR; NECROSIS-FACTOR-ALPHA;

D O I：

10.1134/S0006297911130049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of YB-1 in DNA reparation and transcription, mRNA splicing and translation are systematized. Results on interactions of YB-1 with cytoskeleton components and its possible role in mRNA localization are discussed. Data on intracellular distribution of YB-1, its redistribution between the nucleus and the cytoplasm, and its secretion and extracellular functions are summarized. The effect of YB-1 on cell differentiation, its involvement in extra- and intracellular signaling pathways, and its role in early embryogenesis are described. The mechanisms of regulation of YB-1 expression in the cell are presented. Special attention is paid to the involvement of YB-1 in oncogenic cell transformation, multiple drug resistance, and dissemination of tumors. Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed.

引用

页码：1402 / 1433

页数：32

共 273 条

[1]

Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity [J].

Ansari, SA ;

Safak, M ;

Gallia, GL ;

Sawaya, BE ;

Amini, S ;

Khalili, K .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :2629-2638

[2]

Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 [J].

Ashizuka, M ;

Fukuda, T ;

Nakamura, T ;

Shirasuna, K ;

Iwai, K ;

Izumi, H ;

Kohno, K ;

Kuwano, M ;

Uchiumi, T .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (18) :6375-6383

[3]

The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1 [J].

Astanehe, A. ;

Finkbeiner, M. R. ;

Hojabrpour, P. ;

To, K. ;

Fotovati, A. ;

Shadeo, A. ;

Stratford, A. L. ;

Lam, W. L. ;

Berquin, I. M. ;

Duronio, V. ;

Dunn, S. E. .

ONCOGENE, 2009, 28 (25) :2406-2418

[4]

Phosphorylation by Akt disables the anti-oncogenic activity of YB-1 [J].

Bader, A. G. ;

Vogt, P. K. .

ONCOGENE, 2008, 27 (08) :1179-1182

[5]

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway [J].

Bader, AG ;

Feits, KA ;

Jiang, N ;

Chang, HW ;

Vogt, PK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12384-12389

[6]

Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation [J].

Bader, AG ;

Vogt, PK .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (06) :2095-2106

[7]

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression [J].

Bargou, RC ;

Jurchott, K ;

Wagener, C ;

Bergmann, S ;

Metzner, S ;

Bommert, K ;

Mapara, MY ;

Winzer, KJ ;

Dietel, M ;

Dorken, B ;

Royer, HD .

NATURE MEDICINE, 1997, 3 (04) :447-450

[8]

Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells [J].

Basaki, Y. ;

Hosoi, F. ;

Oda, Y. ;

Fotovati, A. ;

Maruyama, Y. ;

Oie, S. ;

Ono, M. ;

Izumi, H. ;

Kohno, K. ;

Sakai, K. ;

Shimoyama, T. ;

Nishio, K. ;

Kuwano, M. .

ONCOGENE, 2007, 26 (19) :2736-2746

[9]

Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells [J].

Basaki, Yuji ;

Taguchi, Ken-ichi ;

Izumi, Hiroto ;

Murakami, Yuichi ;

Kubo, Takuya ;

Hosoi, Fumihito ;

Watari, Kosuke ;

Nakano, Kenji ;

Kawaguchi, Hidetoshi ;

Ohno, Shinji ;

Kohno, Kimitoshi ;

Ono, Mayumi ;

Kuwano, Michihiko .

EUROPEAN JOURNAL OF CANCER, 2010, 46 (05) :954-965

[10]

YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification [J].

Bergmann, S ;

Royer-Pokora, B ;

Fietze, E ;

Jürchott, K ;

Hildebrandt, B ;

Trost, D ;

Leenders, F ;

Claude, JC ;

Theuring, F ;

Bargou, R ;

Dietel, M ;

Royer, HD .

CANCER RESEARCH, 2005, 65 (10) :4078-4087

← 1 2 3 4 5 6 7 8 9 10 →