Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity

被引：831

作者：

Yu, SJ

Kang, MW

Chang, HC ^{[1
]}

Chen, KM

Yu, YC

机构：

[1] Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

[2] Genom Res Ctr, Tokyo 115, Japan

[3] Acad Sinica, Inst Phys, Taipei 115, Taiwan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 50期

关键词：

D O I：

10.1021/ja0567081

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diamond nanocrystals emit bright fluorescence at 600-800 nm after irradiation by a 3 MeV proton beam (5 × 1015 ions/cm2) and annealing at 800 °C (2 h) in vacuum. The irradiation/annealing process yields high concentrations of nitrogen-vacancy defect centers (∼107 centers/μm3), making possible visualization of the individual 100 nm diamond crystallites using a fluorescence microscope. The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity. The nanomaterial can have far-reaching biological applications. Copyright © 2005 American Chemical Society.

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页码：17604 / 17605

页数：2

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