Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide

被引：21

作者：

Matsuo, J ^{[1
]}

Kobayashi, S ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期

关键词：

asymmetric reaction; alkylation; lactam; lactone;

D O I：

10.1016/S0040-4039(98)02235-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9723 / 9726

页数：4

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