Proteases in apoptosis

被引:58
作者
Zhivotovsky, B [1 ]
Burgess, DH [1 ]
Orrenius, S [1 ]
机构
[1] KAROLINSKA INST,DIV TOXICOL,INST ENVIRONM MED,S-17177 STOCKHOLM,SWEDEN
来源
EXPERIENTIA | 1996年 / 52卷 / 10-11期
关键词
apoptosis; proteases; ICE-like proteases; protein substrates;
D O I
10.1007/BF01920106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The interleukin-1 beta-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide insight into the role of protease(s) in apoptosis. Although it appears that ICE family members play a most important role in promoting apoptotic cell death, evidence has been advanced that other proteases are also involved in sequential or parallel steps of apoptosis, Activation of a particular protease dan lead to processing molecules either of the same or different proteases, leading to an activation of a protease cascade. Here we attempt to summarize the current thinking concerning these proteases and their involvement in apoptosis.
引用
收藏
页码:968 / 978
页数:11
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