Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study

被引：41

作者：

Cheng, Allen C. ^{[1
,2
]}

Kotsimbos, Tom ^{[2
]}

Kelly, Heath A. ^{[4
]}

Irving, Louis B. ^{[3
,4
]}

Bowler, Simon D. ^{[6
]}

Brown, Simon G. A. ^{[5
]}

Holmes, Mark ^{[7
,8
]}

Jenkins, Christine R. ^{[9
,10
]}

Thompson, Philip ^{[6
]}

Simpson, Graham ^{[11
]}

Wood-Baker, Richard ^{[12
]}

Senanayake, Sanjaya N. ^{[13
,14
]}

Brady, Stephen J.

Paterson, David L. ^{[15
,16
]}

Wark, Peter A. ^{[17
,18
]}

Upham, John W. ^{[15
]}

Korman, Tony M.

Dwyer, Dominic E. ^{[9
,19
]}

Waterer, Grant W. ^{[5
]}

Kelly, Paul M. ^{[14
]}

机构：

[1] Monash Univ, Dept Epidemiol & Prevent Med, Clayton, Vic 3800, Australia

[2] Alfred Hosp, Melbourne, Vic, Australia

[3] Royal Melbourne Hosp, Melbourne, Vic, Australia

[4] Univ Melbourne, Melbourne, Vic 3010, Australia

[5] Royal Perth Hosp, Perth, WA, Australia

[6] Univ Western Australia, Nedlands, WA 6009, Australia

[7] Univ Adelaide, Adelaide, SA 5005, Australia

[8] Royal Adelaide Hosp, Adelaide, SA, Australia

[9] Univ Sydney, Sydney, NSW 2006, Australia

[10] Concord Hosp, Sydney, NSW, Australia

[11] Cairns Base Hosp, Cairns, Qld, Australia

[12] Royal Hobart Hosp, Hobart, Tas, Australia

[13] Canberra Hosp, Canberra, ACT, Australia

[14] Australian Natl Univ, Canberra, ACT 0200, Australia

[15] Univ Queensland, Brisbane, Qld 4072, Australia

[16] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia

[17] Univ Newcastle, Callaghan, NSW 2308, Australia

[18] John Hunter Hosp, Newcastle, NSW, Australia

[19] Westmead Hosp, Westmead, NSW, Australia

来源：

VACCINE | 2011年 / 29卷 / 43期

基金：

英国医学研究理事会;

关键词：

Influenza complications; Case control studies; Influenza vaccines; PREVENTING HOSPITALIZATION; SENTINEL SURVEILLANCE; ELDERLY PERSONS; VACCINATION; PNEUMONIA; MORTALITY; REDUCTION; BENEFITS; DESIGNS; IMPACT;

D O I：

10.1016/j.vaccine.2011.07.087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between Marchand November 2010,1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：7320 / 7325

页数：6

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