Imaging features of bone metastases in patients with gastrointestinal stromal tumors

被引:24
作者
Jati, Anupma [3 ]
Tatli, Servet [1 ]
Morgan, Jeffrey A. [4 ]
Glickman, Jonathan N. [2 ]
Demetri, George D. [4 ]
Van den Abbele, Annick [3 ]
Silverman, Stuart G. [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiol, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Oncol, Boston, MA 02115 USA
关键词
gastrointestinal stromal tumors; metastases; bone; positron-emission tomography and computed tomography; PROGNOSIS;
D O I
10.4261/1305-3825.DIR.5179-11.1
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
PURPOSE To determine the prevalence and imaging features, of bone: metastases in patients with gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS The medical records of 190 'patients with pathologically proven GISTs were reviewed, and patients with bone metastases were identified. Computed tomography (CT) scans of the chest, abdomen, and pelvis were examined for features of bone metastases, and findings were correlated with the results of positron-emission tomography (PET) and histopathology. RESULTS Of 190 GIST patients, six (3.2%) had bone metastases: four patients had multiple bone metastases, and two patients had a solitary metastasis. The maximum diameter of the metastases ranged from 2 to 40 mm, and they most commonly involved the vertebrae, ribs, pelvic bone's, and femurs: All lesions were well-marginated and lytic. A soft tissue component was identified in three patients. The bone metastases showed intense fluorine-18 fluorodeoxyglucose..:(FOG) uptake. After treatment with imatinib mesylate in three patients, the bone metastases developed peripheral sclerosis on CT and became, less FOG-avid on PET. All six primary tumors were morphologically high-grade with high mitotic rates and necrosis. CONCLUSION Bone metastases from GISTs are uncommon; when detected with CT, they are characterized by single of multiple lytic lesions with or without soft tissue involvement. A sclerotic rim may appear around the metastatic lesions in response to treatment. Similar to the disease in other sites bone metastases show intense FDG uptake, which decreases following :treatment.
引用
收藏
页码:391 / 396
页数:6
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