Negative control elements of the cell cycle in human tumors

被引：38

作者：

Adams, PD

Kaelin, WG

机构：

[1] Univ Penn, Fox Chase Canc Ctr, Philadelphia, PA 19104 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(98)80123-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or indirectly, inactivated in the majority of human tumors. Recent studies have provided new mechanistic insights into how these proteins regulate cell growth in response to various intracellular and extracellular signals.

引用

收藏

页码：791 / 797

页数：7

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