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Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis

被引：32
作者：
McDougall, K
Kubu, C
Verdi, JM
Meakin, SO
机构：
[1] John P Robarts Res Inst, Neurodegenerat Grp, London, ON N6A 5K8, Canada
[2] John P Robarts Res Inst, Lab Stem Cell Biol, London, ON N6A 5K8, Canada
[3] John P Robarts Res Inst, Lab Neural Signaling, London, ON N6A 5K8, Canada
[4] Univ Western Ontario, Dept Physiol, London, ON N6A 5C1, Canada
[5] Univ Western Ontario, Dept Biochem, London, ON N6A 5C1, Canada
[6] Univ Western Ontario, Grad Program Neurosci, London, ON N6A 5C1, Canada
来源：
MECHANISMS OF DEVELOPMENT | 2001年 / 103卷 / 1-2期
基金：
加拿大健康研究院;
关键词：
FRS2; FRS3; SNT1; SNT2; alpha; beta; neural tube; nerve growth factor; fibroblast growth factor; Trk receptors; neurotrophins; gene expression; signaling adaptor protein; mouse; embryogenesis; embryo; patterning; RNA; in situ; PCR;
D O I：
10.1016/S0925-4773(01)00337-9
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) are involved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS3 and FRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：145 / 148
页数：4
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