Co-transport of H+/Cl- by a synthetic prodigiosin mimic

被引:124
作者
Gale, PA [1 ]
Light, ME
McNally, B
Navakhun, K
Sliwinski, KE
Smith, BD
机构
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
关键词
D O I
10.1039/b503906a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An amidopyrrole with appended imidazole group can bind and co-transport H+/Cl- across vesicle membranes much more effectively than an analogue with an appended pyridyl group.
引用
收藏
页码:3773 / 3775
页数:3
相关论文
共 26 条
[1]   Defective acidification in human breast tumor cells and implications for chemotherapy [J].
Altan, N ;
Chen, Y ;
Schindler, M ;
Simon, SM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1583-1598
[2]  
[Anonymous], CRIT REV MICROBIOL
[3]  
BASHA A, 1977, TETRAHEDRON LETT, V18, P4171, DOI DOI 10.1016/S0040-4039(01)83457-2
[4]   Seeing red: The story of prodigiosin [J].
Bennett, JW ;
Bentley, R .
ADVANCES IN APPLIED MICROBIOLOGY, VOL 47, 2000, 47 :1-32
[5]   TRIS[(2-PYRIDYL)METHYL]AMINE (TPA) AND (+)-BIS[(2-PYRIDYL)METHYL]-1-(2-PYRIDYL)-ETHYLAMINE (α-METPA) [J].
Canary, JW ;
Wang, YH ;
Roy, R ;
Que, L ;
Miyake, H .
INORGANIC SYNTHESES, VOL 32, 1998, 32 :70-75
[6]   ANTIMALARIAL ACTIVITY OF PRODIGIOSIN [J].
CASTRO, AJ .
NATURE, 1967, 213 (5079) :903-&
[7]   A mechanism for tamoxifen-mediated inhibition of acidification [J].
Chen, Y ;
Schindler, M ;
Simon, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18364-18373
[8]   Chemistry and biology of roseophilin and the prodigiosin alkaloids:: A survey of the last 2500 years [J].
Fürstner, A .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (31) :3582-3603
[9]  
GALE PA, 2005, CHEM COMMUN
[10]   Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification [J].
Gottlieb, RA ;
Nordberg, J ;
Skowronski, E ;
Babior, BM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) :654-658