Kinetochores' gripping feat: conformational wave or biased diffusion?

被引：41

作者：

Asbury, Charles L. ^{[1
]}

Tien, Jerry F. ^{[2
]}

Davis, Trisha N. ^{[2
]}

机构：

[1] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 01期

关键词：

MICROTUBULE ATTACHMENT SITE; YEAST DASH COMPLEX; DAM1; COMPLEX; MOLECULAR ARCHITECTURE; CHROMOSOME MOTION; NDC80; FISSION YEAST; FORCE PRODUCTION; RING COMPLEX; SKA COMPLEX;

D O I：

10.1016/j.tcb.2010.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Climbing up a cliff while the rope unravels underneath your fingers does not sound like a well-planned adventure. Yet chromosomes face a similar challenge during each cell division. Their alignment and accurate segregation depends on staying attached to the assembling and disassembling tips of microtubule fibers. This coupling is mediated by kinetochores, intricate machines that attach chromosomes to an ever-changing microtubule substrate. Two models for kinetochore-microtubule coupling were proposed a quarter century ago: conformational wave and biased diffusion. These models differ in their predictions for how coupling is performed and regulated. The availability of purified kinetochore proteins has enabled biochemical and biophysical analyses of the kinetochore-microtubule interface. Here, we discuss what these studies reveal about the contributions of each model.

引用

页码：38 / 46

页数：9

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