Therapy for diastolic heart failure

被引:34
作者
Little, WC [1 ]
Brucks, S [1 ]
机构
[1] Wake Forest Univ, Sch Med, Sect Cardiol, Dept Med, Winston Salem, NC 27157 USA
关键词
D O I
10.1016/j.pcad.2005.02.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is little objective to guide the therapy of patients with diastolic heart failure. Beacuse of the similarities of pathophysiology abnormalities in diastolic and systolic heart failure, it is a reasonable inference to suggest that the proven therapy for systolic heart failure may also be of benefit in patients with diastolic heart failure. Treatment of underlying or exacerbating conditions in diastolic heart failure, such as hypertension, left ventricular hypertrophy, ischemia, diabetes, anemia, obesity and pulmonary disease is an important means of managing diastolic heart failure. Control of systolic blood pressure is effective in improving and preventing the development of diastolic heart failure. Treament of diastolic heart failure is most effective when it is associated with hypertension. Production of systolic arterial pressure acutely reduces pulmonary congestion, ischemia, and chronically may lead to regression of left ventricular hypertrophy. Patients with diastolic heart failure in the absence of hypertension are very difficult to treat. © 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:380 / 388
页数:9
相关论文
共 62 条
[1]   ANGIOTENSIN-CONVERTING ENZYME-INHIBITION DOES NOT SUPPRESS PLASMA ANGIOTENSIN-II INCREASE DURING EXERCISE IN HUMANS [J].
ALDIGIER, JC ;
HUANG, H ;
DALMAY, F ;
LARTIGUE, M ;
BAUSSANT, T ;
CHASSAIN, AP ;
LEROUXROBERT, C ;
GALEN, FX .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 21 (02) :289-295
[2]   Changes in early and late diastolic filling patterns induced by long-term adrenergic beta-blockade in patients with idiopathic dilated cardiomyopathy [J].
Andersson, B ;
Caidahl, K ;
diLenarda, A ;
Warren, SE ;
Goss, F ;
Waldenstrom, A ;
Persson, S ;
Wallentin, I ;
Hjalmarson, A ;
Waagstein, F .
CIRCULATION, 1996, 94 (04) :673-682
[3]   Evaluation and management of diastolic heart failure [J].
Angeja, BG ;
Grossman, W .
CIRCULATION, 2003, 107 (05) :659-663
[4]   Prevention of heart failure in patients in the Heart Outcomes Prevention Evaluation (HOPE) study [J].
Arnold, JMO ;
Yusuf, S ;
Young, J ;
Mathew, J ;
Johnstone, D ;
Avezum, A ;
Lonn, E ;
Pogue, J ;
Bosch, J .
CIRCULATION, 2003, 107 (09) :1284-1290
[5]   Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease [J].
Brilla, CG ;
Funck, RC ;
Rupp, H .
CIRCULATION, 2000, 102 (12) :1388-1393
[6]   Relation of anemia to diastolic heart failure and the effect on outcome [J].
Brucks, S ;
Little, WC ;
Chao, T ;
Rideman, RL ;
Upadhya, B ;
Wesley-Farrington, D ;
Sane, DC .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (08) :1055-1057
[7]   Coupled systolic-ventricular and vascular stiffening with age implications for pressure regulation and cardiac reserve in the elderly [J].
Chen, CH ;
Nakayama, M ;
Nevo, E ;
Fetics, BJ ;
Maughan, WL ;
Kass, DA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (05) :1221-1227
[8]   Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals [J].
Chen, CH ;
Nakayama, M ;
Talbot, M ;
Nevo, E ;
Fetics, B ;
Gerstenblith, G ;
Becker, LC ;
Kass, DA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (06) :1602-1609
[9]   MECHANISM OF AUGMENTED RATE OF LEFT-VENTRICULAR FILLING DURING EXERCISE [J].
CHENG, CP ;
IGARASHI, Y ;
LITTLE, WC .
CIRCULATION RESEARCH, 1992, 70 (01) :9-19
[10]   The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure [J].
Cheng, CP ;
Ukai, T ;
Onishi, K ;
Ohte, N ;
Suzuki, M ;
Zhang, ZS ;
Cheng, HJ ;
Tachibana, H ;
Igawa, A ;
Little, WC .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (04) :H1853-H1860