Structure and function of cyclic nucleotide-gated channels

被引:415
作者
Zagotta, WN [1 ]
Siegelbaum, SA [1 ]
机构
[1] COLUMBIA UNIV,HOWARD HUGHES MED INST,CTR NEUROBIOL & BEHAV,DEPT PHARMACOL,NEW YORK,NY 10032
关键词
photoreceptor; olfaction; potassium channel; sodium channel; calcium channel;
D O I
10.1146/annurev.ne.19.030196.001315
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cyclic nucleotide-gated (CNG) channels play important roles in both visual (Yau & Baylor 1989) and olfactory (Zufall et al 1994) signal transduction. The cloning of the gene coding for a rod photoreceptor channel (Kaupp et al 1989) and the subsequent cloning of related genes from olfactory neurons (Dhallan et al 1990, Ludwig et al 1990, Goulding et al 1992) has sparked much progress over the past several years in elucidating the structural bases for the function of the CNG channels. One of the surprising features to emerge from these cloning studies was that the CNG channels are structurally homologous to the voltage-gated channels (Jan & Jan 1990) despite the fact that the CNG channels are gated by the binding of a ligand-cAMP or cGMP-and not by voltage. In this review we focus on recent studies of the relationship between the structure and function of the CNG channels. Given the homology between CNG channels and voltage-gated channels, such studies are likely to provide important general information about the structure and function of a wide variety of channel types.
引用
收藏
页码:235 / 263
页数:29
相关论文
共 136 条
[1]   DEVELOPMENTAL AND TISSUE-SPECIFIC EXPRESSION OF THE ROD PHOTORECEPTOR CGMP-GATED ION CHANNEL GENE [J].
AHMAD, I ;
REDMOND, LJ ;
BARNSTABLE, CJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (01) :463-470
[2]   NON-SELECTIVE CONDUCTANCE IN CALCIUM CHANNELS OF FROG-MUSCLE - CALCIUM SELECTIVITY IN A SINGLE-FILE PORE [J].
ALMERS, W ;
MCCLESKEY, EW .
JOURNAL OF PHYSIOLOGY-LONDON, 1984, 353 (AUG) :585-608
[3]   CONTROL OF LIGAND SPECIFICITY IN CYCLIC NUCLEOTIDE-GATED CHANNELS FROM ROD PHOTORECEPTORS AND OLFACTORY EPITHELIUM [J].
ALTENHOFEN, W ;
LUDWIG, J ;
EISMANN, E ;
KRAUS, W ;
BONIGK, W ;
KAUPP, UB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9868-9872
[4]   FUNCTIONAL EXPRESSION OF A PROBABLE ARABIDOPSIS-THALIANA POTASSIUM CHANNEL IN SACCHAROMYCES-CEREVISIAE [J].
ANDERSON, JA ;
HUPRIKAR, SS ;
KOCHIAN, LV ;
LUCAS, WJ ;
GABER, RF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3736-3740
[5]   ASSEMBLY OF MAMMALIAN VOLTAGE-GATED POTASSIUM CHANNELS - EVIDENCE FOR AN IMPORTANT ROLE OF THE FIRST TRANSMEMBRANE SEGMENT [J].
BABILA, T ;
MOSCUCCI, A ;
WANG, HY ;
WEAVER, FE ;
KOREN, G .
NEURON, 1994, 12 (03) :615-626
[6]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A DROSOPHILA CYCLIC NUCLEOTIDE-GATED CHANNEL PRESENT IN EYES AND ANTENNAE [J].
BAUMANN, A ;
FRINGS, S ;
GODDE, M ;
SEIFERT, R ;
KAUPP, UB .
EMBO JOURNAL, 1994, 13 (21) :5040-5050
[7]  
BAYLOR DA, 1979, J PHYSIOL-LONDON, V288, P613
[8]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A CYCLIC NUCLEOTIDE-GATED CHANNEL FROM RABBIT AORTA [J].
BIEL, M ;
ALTENHOFEN, W ;
HULLIN, R ;
LUDWIG, J ;
FREICHEL, M ;
FLOCKERZI, V ;
DASCAL, N ;
KAUPP, UB ;
HOFMANN, F .
FEBS LETTERS, 1993, 329 (1-2) :134-138
[9]   ANOTHER MEMBER OF THE CYCLIC NUCLEOTIDE-GATED CHANNEL FAMILY, EXPRESSED IN TESTIS, KIDNEY, AND HEART [J].
BIEL, M ;
ZONG, XG ;
DISTLER, M ;
BOSSE, E ;
KLUGBAUER, N ;
MURAKAMI, M ;
FLOCKERZI, V ;
HOFMANN, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3505-3509
[10]   ROD AND CONE PHOTORECEPTOR CELLS EXPRESS DISTINCT GENES FOR CGMP-GATED CHANNELS [J].
BONIGK, W ;
ALTENHOFEN, W ;
MULLER, F ;
DOSE, A ;
ILLING, M ;
MOLDAY, RS ;
KAUPP, UB .
NEURON, 1993, 10 (05) :865-877