Trisomy 8 is a characteristic finding in pleuropulmonary blastoma

被引：34

作者：

Novak, R ^{[1
]}

Dasu, S ^{[1
]}

Agamanolis, D ^{[1
]}

Herold, W ^{[1
]}

Malone, J ^{[1
]}

Waterson, J ^{[1
]}

机构：

[1] NE OHIO UNIV,COLL MED,ROOTSTOWN,OH 44272

来源：

PEDIATRIC PATHOLOGY & LABORATORY MEDICINE | 1997年 / 17卷 / 01期

关键词：

pleuropulmonary blastoma; trisomy; 8;

D O I：

10.1080/107710497175056

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The cytogenetic findings in pleuropulmonary blastoma (PPB) have not been widely studied and reported and are of interest in view of the implications that PPB has for additional tumors in the patient and the patient's relatives. Using standard tumor cytogenetic methodology, we investigated three cases of PPB encountered in our institution over a 5-year period. Trisomy 8 was the only karyotypic abnormality in a localized type 2 PPB and was present with other abnormalities in another type 2 PPB and a massive type 3 PPB. Review of the literature yielded three additional karyotyped PPBs; all had trisomy 8 as part of the abnormalities detected. Trisomy 8 appears to be a characteristic of PPB and may be related to the development of PPB and related tumors.

引用

页码：99 / 103

页数：5

共 18 条

[1] CHROMOSOMAL-ABNORMALITIES IN 47 PEDIATRIC BRAIN-TUMORS [J].