Erythropoietin: A novel neuroprotective cytokine

被引：94

作者：

Bartesaghi, S

Marinovich, M

Corsini, E

Galli, CL

Viviani, B

机构：

[1] Univ Milan, Dept Pharmacol Sci, Toxicol Lab, I-20133 Milan, Italy

[2] Univ Milan, Dept Pharmacol Sci, Ctr Excellence Neurodegenerat Dis, I-20133 Milan, Italy

来源：

NEUROTOXICOLOGY | 2005年 / 26卷 / 05期

关键词：

erythropoietin; neuroprotection; apoptosis; inflammation; signal transduction; BDNF;

D O I：

10.1016/j.neuro.2005.01.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Erythropoietin (Epo), the principal regulator of erythroids progenitor cells, greatly improves neuronal survival. A wide variety, of experimental studies have shown that both Epo and the EpoR are functionally, expressed in the nervous System and that this cytokine exerts a remarkable neuroprotection both in vitro against different neurotoxicants and in animal models of nervous system disorders. Aim of this review is to summarize the neuroprotective properties of Epo and to outline the molecular mechanisms involved in order to point out the signal transduction pathway which may represent the potential basis for future strategies against neuronal injury. (c) 2005 Elsevier Inc. All rights reserved.

引用

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页码：923 / 928

页数：6

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