Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model

被引：18

作者：

Baskerville, Tracey A.

McCabe, Christopher

Weir, Christopher J. ^{[2
]}

Macrae, I. Mhairi ^{[1
]}

Holmes, William M.

机构：

[1] Univ Glasgow, Wellcome Surg Inst, Inst Neurosci & Psychol, Glasgow Expt MRI Ctr, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2012年 / 32卷 / 06期

关键词：

ASL; CBF; stroke; CEREBRAL-BLOOD-FLOW; FOCAL ISCHEMIA; PERFUSION; INVERSION; OCCLUSION; BRAIN;

D O I：

10.1038/jcbfm.2012.19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Arterial spin labelling (ASL) is increasingly available for noninvasive cerebral blood flow (CBF) measurement in stroke research. Here, a pseudo-continuous ASL technique (pCASL) was evaluated against Tc-99m-D, L-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) autoradiography in a rat stroke model. The Tc-99m-HMPAO was injected (intravenously, 225 MBq) during pCASL acquisition. The pCASL and Tc-99m-HMPAO autoradiography CBF measures, relative to the contralateral hemisphere, were in good agreement across the spectrum of flow values in normal and ischemic tissues. The pCASL-derived quantitative regional CBF values (contralateral: 157 to 177 mL/100 g per minute; ipsilateral: 9 to 104 mL/100 g per minute) were consistent with the literature values. The data show the potential utility of pCASL for CBF assessment in a rat stroke model. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 973-977; doi:10.1038/jcbfm.2012.19; published online 4 April 2012

引用

页码：973 / 977

页数：5

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