Use of Inactivated Escherichia coli Enterotoxins To Enhance Respiratory Mucosal Adjuvanticity during Vaccination in Swine

被引：10

作者：

Barrette, Roger W. ^{[2
]}

Szczepanek, Steven M. ^{[3
,4
]}

Rood, Debra ^{[3
]}

Challa, Sreerupa ^{[2
]}

Avery, Naomi ^{[2
]}

Vajdy, Michael ^{[5
]}

Kramer, Ed ^{[4
]}

Rodriguez, Luis ^{[4
]}

Silbart, Lawrence K. ^{[1
,2
,3
]}

机构：

[1] Univ Connecticut, Dept Allied Hlth Sci, CANR, Ctr Excellence Vaccine Res, Storrs, CT 06269 USA

[2] Univ Connecticut, Dept Anim Sci, Storrs, CT 06269 USA

[3] Univ Connecticut, Dept Allied Hlth Sci, Storrs, CT 06229 USA

[4] ARS, USDA, Plum Isl Anim Dis Ctr, Greenport, NY 11944 USA

[5] Novartis Vaccines & Diagnost Inc, Emeryville, CA 94563 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2011年 / 18卷 / 11期

关键词：

HEAT-LABILE ENTEROTOXIN; DELIVERY; MUTANT; SYSTEM;

D O I：

10.1128/CVI.05273-11

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In order to augment responses to respiratory vaccines in swine, various adjuvants were intranasally coadministered with a foot-and-mouth disease virus (FMDV) antigen to pigs. Detoxified Escherichia coli enterotoxins LTK63 and LTR72 enhanced antigen-specific mucosal and systemic immunity, demonstrating their efficacy as adjuvants for nonreplicating antigens upon intranasal immunization in swine.

引用

页码：1996 / 1998

页数：3

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