Micro- and nanoengineering for stem cell biology: the promise with a caution

被引：63

作者：

Kshitiz ^{[1
,2
]}

Kim, Deok-Ho ^{[1
,2
,3
]}

Beebe, David J. ^{[4
]}

Levchenko, Andre ^{[1
,2
]}

机构：

[1] Johns Hopkins Med Inst, Dept Biomed Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Inst Cell Engn, Baltimore, MD 21205 USA

[3] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[4] Univ Wisconsin, Dept Biomed Engn, Madison, WI USA

来源：

TRENDS IN BIOTECHNOLOGY | 2011年 / 29卷 / 08期

关键词：

MICROCHANNEL BIOREACTORS; CULTURE; GRADIENT; MICROFLUIDICS; DESIGN; DEVICE; SCALE; GENERATION; EXPRESSION; MOLECULES;

D O I：

10.1016/j.tibtech.2011.03.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Current techniques used in stem cell research only crudely mimic the physiological complexity of the stem cell niches. Recent advances in the field of micro- and nanoengineering have brought an array of in vitro cell culture models that have enabled development of novel, highly precise and standardized tools that capture physiological details in a single platform, with greater control, consistency, and throughput. In this review, we describe the micro- and nanotechnology-driven modern toolkit for stem cell biologists to design novel experiments in more physiological microenvironments with increased precision and standardization, and caution them against potential challenges that the modern technologies might present.

引用

页码：399 / 408

页数：10

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