A study of the effects of lorazepam and dextromethorphan on the response to cortical I Hz repetitive transcranial magnetic stimulation

被引：27

作者：

Fitzgerald, PB ^{[1
]}

Benitez, J

Oxley, T

Daskalakis, JZ

de Castella, AR

Kulkarni, J

机构：

[1] Alfred & Monash Univ, Dept Psychol Med, Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia

[2] Clarke Div, Ctr Addict & Mental Hlth, Toronto, ON, Canada

来源：

NEUROREPORT | 2005年 / 16卷 / 13期

关键词：

cortical inhibition; dextromethorphan; lorazepam; plasticity; repetitive transcranial magnetic stimulation;

D O I：

10.1097/01.wnr.0000177005.14108.f1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of lorazepam and dextromethorphan on the responses to 1 Hz repetitive transcranial magnetic stimulation applied to the left human motor cortex. Lorazepam, dextromethorphan or placebo was administered to 45 normal controls in a double-blind fashion 2.5 h before the repetitive transcranial magnetic stimulation procedure. Motor cortical excitability was measured with single transcranial magnetic stimulation pulses before and after 15 min of 1 Hz repetitive transcranial magnetic stimulation applied at supra-threshold intensity. 1 Hz repetitive transcranial magnetic stimulation resulted in a decrease in motor cortical excitability in the placebo group but not in the groups taking lorazepam or dextromethorphan. These results suggest that cortical responses to I Hz repetitive transcranial magnetic stimulation are dependent on activity at both gamma-aminobutyric acid and N-methyl-D-asparate receptor systems.

引用

页码：1525 / 1528

页数：4

共 23 条

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