Rapid increase of pneumococcal resistance to beta-lactam and other antibiotics in isolates from the respiratory tract (Nagasaki, Japan: 1975-1994)

被引：13

作者：

Rikitomi, N ^{[1
]}

Sow, PS ^{[1
]}

Watanabe, K ^{[1
]}

Nunez, DS ^{[1
]}

Martinez, G ^{[1
]}

Nagatake, T ^{[1
]}

机构：

[1] FANN HOSP,DEPT INFECT DIS,DAKAR,SENEGAL

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1996年 / 40卷 / 12期

关键词：

Streptococcus pneumoniae; penicillin-resistant pneumococcus; multiply resistant pneumococcus; respiratory infection;

D O I：

10.1111/j.1348-0421.1996.tb01158.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The susceptibility of 101 pneumococcal isolates from the respiratory tract during 1991-1994 was examined and compared with the susceptibility of isolates over the period of 1975-1990, A rapid increase of resistance was seen not only to penicillin but also other antimicrobial agents. During 1991-1994, 38% of all the isolates were resistant to penicillin. The rates of resistance during this period were 16-23% for three newer cephalosporins, 18% for imipenem, 69% for tetracycline, 31% for erythromycin, 20% for chloramphenicol and 9% for clindamycin. The use of antibiotics within one month prior to pneumococcal isolation was correlated with penicillin resistance (P < 0.05). Serotyping of the isolates by antiserum revealed differences in predominant types between penicillin-resistant (19F, 23F, 4) and -susceptible isolates (15, 4, 11A). Our data suggests that anti-pneumococcal antibiotics should be carefully chosen on the basis of susceptibility tests.

引用

页码：899 / 905

页数：7