The origin and evolution of cell types

被引：479

作者：

Arendt, Detlev ^{[1
,2
]}

Musser, Jacob M. ^{[1
]}

Baker, Clare V. H. ^{[3
]}

Bergman, Aviv ^{[4
,5
,6
]}

Cepko, Connie ^{[7
,8
]}

Erwin, Douglas H. ^{[6
,9
]}

Pavlicev, Mihaela ^{[10
]}

Schlosser, Gerhard ^{[11
,12
]}

Widder, Stefanie ^{[13
]}

Laubichler, Manfred D. ^{[6
,14
,15
]}

Wagner, Gunter P. ^{[16
,17
,18
,19
]}

机构：

[1] European Mol Biol Lab, Dev Biol Unit, Meyerhofstr 1, D-69012 Heidelberg, Germany

[2] Heidelberg Univ, Ctr Organismal Studies, Neuenheimer Feld 230, D-69120 Heidelberg, Germany

[3] Univ Cambridge, Dept Physiol Dev & Neurosci, Anat Bldg,Downing St, Cambridge CB2 3DY, England

[4] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Dept Syst & Computat Biol, 1301 Morris Pk Ave, Bronx, NY 10461 USA

[5] Albert Einstein Coll Med, Dept Pathol, 1301 Morris Pk Ave, Bronx, NY 10461 USA

[6] Santa Fe Inst, 1399 Hyde Pk Rd, Santa Fe, NM 87501 USA

[7] Harvard Med Sch, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA

[8] Harvard Med Sch, Howard Hughes Med Inst, Dept Ophthalmol, Boston, MA 02115 USA

[9] Smithsonian Inst, Dept Paleobiol, MRC 121, POB 37012, Washington, DC 20013 USA

[10] Cincinnati Childrens Hosp Med Ctr, Perinatal Inst, Cincinnati, OH 45229 USA

[11] Sch Nat Sci, Biomed Sci Bldg,Newcastle Rd, Galway, Ireland

[12] Regenerat Med Inst REMEDI, Biomed Sci Bldg,Newcastle Rd, Galway, Ireland

[13] Univ Vienna, Dept Microbial Ecol & Ecosyst Sci, CUBE, Althanstr 14, A-1090 Vienna, Austria

[14] Arizona State Univ, Sch Life Sci, POB 4501, Tempe, AZ 85287 USA

[15] Marine Biol Lab, 7 MBL St, Woods Hole, MA 02543 USA

[16] Yale Univ, Yale Syst Biol Inst, New Haven, CT 06511 USA

[17] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06511 USA

[18] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, 333 Cedar St, New Haven, CT 06510 USA

[19] Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI 48201 USA

来源：

NATURE REVIEWS GENETICS | 2016年 / 17卷 / 12期

基金：

欧洲研究理事会;

关键词：

REGULATES DENDRITIC SPINE; GENE-EXPRESSION; TRANSCRIPTION FACTORS; NERVOUS-SYSTEM; CONE PHOTORECEPTORS; HUMAN ENDOMETRIUM; N-CADHERIN; C-ELEGANS; PROTEIN COMPLEXES; STROMAL CELLS;

D O I：

10.1038/nrg.2016.127

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cell types are the basic building blocks of multicellular organisms and are extensively diversified in animals. Despite recent advances in characterizing cell types, classification schemes remain ambiguous. We propose an evolutionary definition of a cell type that allows cell types to be delineated and compared within and between species. Key to cell type identity are evolutionary changes in the 'core regulatory complex' (CoRC) of transcription factors, that make emergent sister cell types distinct, enable their independent evolution and regulate cell type-specific traits termed apomeres. We discuss the distinction between developmental and evolutionary lineages, and present a roadmap for future research.

引用

页码：744 / 757

页数：14

共 170 条

[1] Structural evolution of cell types by step-wise assembly of cellular modules [J].