Structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase inferred from crystallography and molecular dynamics

被引：26

作者：

de Ruyck, J ^{[1
]}

Rothman, SC

Poulter, CD

Wouters, J

机构：

[1] Univ Namur, Lab Chim Biol Struct, B-5000 Namur, Belgium

[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 03期

关键词：

macromolecules crystallography; IDI-2; flavoprotein; molecular modelling;

D O I：

10.1016/j.bbrc.2005.10.114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystal structures of Thermus thermophilus and Bacillus subtilis type 2 IPP isomerases were combined to generate an almost complete model of the FMN-bound Structure of the enzyme. In contrast to previous studies, positions of flexible loops were obtained and carefully analyzed by molecular dynamics. Docking simulations find a unique putative binding site for the IPP substrate.(c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1515 / 1518

页数：4

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