Resveratrol in Solid Lipid Nanoparticles

被引：42

作者：

Carlotti, Maria Eugenia ^{[1
]}

Sapino, Simona ^{[1
]}

Ugazio, Elena ^{[1
]}

Gallarate, Marina ^{[1
]}

Morel, Silvia ^{[2
]}

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

[2] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, Novara, Italy

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 04期

关键词：

Photostability; resveratrol; skin uptake; solid lipid nanoparticles; tetradecyl-gamma-cyclodextrin; PERCUTANEOUS-ABSORPTION; ANTIOXIDANT ACTIVITY; CELL-PROLIFERATION; VITIS-VINIFERA; CYCLODEXTRINS; WINE; SLN; OXIDATION; COMPOUND; ALCOHOL;

D O I：

10.1080/01932691.2010.548274

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This article investigates the possibility of producing solid lipid nanoparticles (SLN) as protective vehicle of resveratrol, an antioxidant characterized by a fast trans-cis isomerization. SLN aqueous dispersions were produced by hot melt homogenization technique and characterized. It was found that the presence of tetradecyl-gamma-cyclodextrin in SLN formulation induced an improvement of nanoparticle characteristics. Moreover, a significant reduction in resveratrol photodegradation was noted when the molecule was entrapped in SLN which became more pronounced in the presence of tetradecyl-gamma-cyclodextrin. A notable in vitro porcine skin accumulation and an increased antioxidative efficacy were observed by entrapping resveratrol in nanoparticles.

引用

页码：465 / 471

页数：7

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