Osteopontin: a potentially important therapeutic target in cancer

被引：81

作者：

Ahmed, Mansoor

Behera, Reeti ^{[2
]}

Chakraborty, Goutam ^{[3
]}

Jain, Shalini ^{[4
]}

Kumar, Vinit ^{[2
]}

Sharma, Priyanka ^{[5
]}

Bulbule, Anuradha ^{[1
]}

Kale, Smita ^{[1
]}

Kumar, Santosh ^{[1
]}

Mishra, Rosalin ^{[1
]}

Raja, Remya ^{[1
]}

Saraswati, Supriya ^{[1
]}

Kaur, Rajinder ^{[1
]}

Soundararajan, Gowrishankar ^{[1
]}

Kumar, Dhiraj ^{[1
]}

Thorat, Dhanashri ^{[1
]}

Sanyal, Megha ^{[1
]}

Ramdasi, Anuja ^{[1
]}

Ghosh, Pompom ^{[1
]}

Kundu, Gopal C. ^{[1
]}

机构：

[1] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India

[2] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[3] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[4] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[5] Univ Calif Riverside, Riverside, CA 92521 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 09期

关键词：

angiogenesis; metastasis; osteopontin; prognostic marker; targeted therapy; tumour-stroma interaction; NF-KAPPA-B; BREAST-CANCER; TUMOR-GROWTH; PROGNOSTIC-SIGNIFICANCE; CRUCIAL ROLE; EXPRESSION; CELLS; INTEGRIN; MACROPHAGES; RECEPTOR;

D O I：

10.1517/14728222.2011.594438

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Introduction: Cancer is an extremely complex disease and most cancer treatments are limited to chemotherapy, radiation and surgery. The progression of tumours towards malignancy requires the interaction of various cytokines, growth factors, transcription factors and effector molecules. Osteopontin is a cytokine-like, calcium-binding, extracelular-matrix-associated member of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. It plays an important role in determining the oncogenic potential of various cancers. The role of osteopontin in various pathophysiological conditions suggests that the alteration in post-translationalmodification result in different functional forms that might change its normal physiological functions. Areas covered: Osteopontin-based anticancer therapy, which may provide a new insight for the effective management of cancer. Expert opinion: A better understanding of the signalling mechanism by which osteopontin promotes tumourigenesis may be useful in crafting novel osteopontin-based anticancer therapy. The role of osteopontin in promoting cancer progression is the subject of in depth investigation and thus targeting osteopontin might be a suitable therapeutic approach for the treatment of cancer.

引用

页码：1113 / 1126

页数：14

共 100 条

[1]

Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells [J].