Contrast agents for MRI

被引：73

作者：

Waters, Emily A. ^{[1
]}

Wickline, Samuel A. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Cardiol, St Louis, MO 63108 USA

来源：

BASIC RESEARCH IN CARDIOLOGY | 2008年 / 103卷 / 02期

关键词：

molecular imaging; nanoparticles; therapy; MRI;

D O I：

10.1007/s00395-008-0711-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.

引用

页码：114 / 121

页数：8

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