Three-dimensional biomaterials for the study of human pluripotent stem cells

被引：194

作者：

Kraehenbuehl, Thomas P. ^{[1
,2
]}

Langer, Robert ^{[1
]}

Ferreira, Lino S. ^{[1
,3
,4
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Hoffmann La Roche Inc, Translat Res Sci, Nutley, NJ 07110 USA

[3] Biocant Ctr Innovat Biotechnol, Cantanhede, Portugal

[4] Univ Coimbra, Ctr Neurosci & Cell Biol, Coimbra, Portugal

来源：

NATURE METHODS | 2011年 / 8卷 / 09期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

EXTRACELLULAR-MATRIX; SELF-RENEWAL; NEURAL CONVERSION; EMBRYOID BODIES; DIFFERENTIATION; GROWTH; HYDROGEL; MUSCLE; MECHANOTRANSDUCTION; ENCAPSULATION;

D O I：

10.1038/nmeth.1671

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

The self-renewal and differentiation of human pluripotent stem cells (hPSCs) have typically been studied in flat, two-dimensional (2D) environments. In this Perspective, we argue that 3D model systems may be needed in addition, as they mimic the natural 3D tissue organization more closely. We survey methods that have used 3D biomaterials for expansion of undifferentiated hPSCs, directed differentiation of hPSCs and transplantation of differentiated hPSCs in vivo.

引用

页码：731 / 736

页数：6

共 63 条

[1]

Biomechanical forces promote embryonic haematopoiesis [J].

Adamo, Luigi ;

Naveiras, Olaia ;

Wenzel, Pamela L. ;

McKinney-Freeman, Shannon ;

Mack, Peter J. ;

Gracia-Sancho, Jorge ;

Suchy-Dicey, Astrid ;

Yoshimoto, Momoko ;

Lensch, M. William ;

Yoder, Mervin C. ;

Garcia-Cardena, Guillermo ;

Daley, George Q. .

NATURE, 2009, 459 (7250) :1131-U120

[2]

Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells [J].

Anderson, DG ;

Levenberg, S ;

Langer, R .

NATURE BIOTECHNOLOGY, 2004, 22 (07) :863-866

[3]

Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro [J].

Baharvand, Hossein ;

Hashemi, Seyed M. ;

Kazemi Ashtian, Saeid ;

Farrokhi, Ali .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2006, 50 (07) :645-652

[4]

Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via αVβ5 integrin [J].

Braam, Stefan R. ;

Zeinstra, Laura ;

Litjens, Sandy ;

Ward-van Oostwaard, Dorien ;

van den Brink, Stieneke ;

van Laake, Linda ;

Lebrin, Franck ;

Kats, Peter ;

Hochstenbach, Ron ;

Passier, Robert ;

Sonnenberg, Arnoud ;

Mummery, Christine L. .

STEM CELLS, 2008, 26 (09) :2257-2265

[5]

Tissue engineering of vascularized cardiac muscle from human embryonic stem cells [J].

Caspi, Oren ;

Lesman, Ayelet ;

Basevitch, Yaara ;

Gepstein, Amira ;

Arbel, Gil ;

Huber, Irit ;

Habib, Manhal ;

Gepstein, Lior ;

Levenberg, Shulamit .

CIRCULATION RESEARCH, 2007, 100 (02) :263-272

[6]

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling [J].

Chambers, Stuart M. ;

Fasano, Christopher A. ;

Papapetrou, Eirini P. ;

Tomishima, Mark ;

Sadelain, Michel ;

Studer, Lorenz .

NATURE BIOTECHNOLOGY, 2009, 27 (03) :275-280

[7]

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells [J].

Chen, Guokai ;

Hou, Zhonggang ;

Gulbranson, Daniel R. ;

Thomson, James A. .

CELL STEM CELL, 2010, 7 (02) :240-248

[8]

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions [J].

Chowdhury, Farhan ;

Li, Yanzhen ;

Poh, Yeh-Chuin ;

Yokohama-Tamaki, Tamaki ;

Wang, Ning ;

Tanaka, Tetsuya S. .

PLOS ONE, 2010, 5 (12)

[9]

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells [J].

D'Amour, Kevin A. ;

Bang, Anne G. ;

Eliazer, Susan ;

Kelly, Olivia G. ;

Agulnick, Alan D. ;

Smart, Nora G. ;

Moorman, Mark A. ;

Kroon, Evert ;

Carpenter, Melissa K. ;

Baetge, Emmanuel E. .

NATURE BIOTECHNOLOGY, 2006, 24 (11) :1392-1401

[10]

Growth Factors, Matrices, and Forces Combine and Control Stem Cells [J].

Discher, Dennis E. ;

Mooney, David J. ;

Zandstra, Peter W. .

SCIENCE, 2009, 324 (5935) :1673-1677

← 1 2 3 4 5 6 7 →