The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)

被引：38

作者：

Gachon, F ^{[1
]}

Gaudray, G ^{[1
]}

Thébault, S ^{[1
]}

Basbous, J ^{[1
]}

Koffi, JA ^{[1
]}

Devaux, C ^{[1
]}

Mesnard, JM ^{[1
]}

机构：

[1] Univ Montpellier 1, CNRS, Lab Infect Retrovirales & Signalisat Cellulaire, Inst Biol, F-34060 Montpellier, France

来源：

FEBS LETTERS | 2001年 / 502卷 / 1-2期

关键词：

basic leucine zipper factor; cAMP response element binding protein-2; C/EBP-homologous protein; cAMP response element site; human T-cell leukemia virus type I;

D O I：

10.1016/S0014-5793(01)02646-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cAMP response element binding protein-2 (CREB-2) is a basic leucine zipper (bZIP) factor that was originally described as a repressor of CRE-dependent transcription but that can also act as a transcriptional activator. Moreover, CREB-2 is able to function in association with the viral Tax protein as an activator of the human T-cell leukemia virus type I (HTLV-I) promoter. Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription. Cotransfection of CHOP with CREB-2 results in decreased activation driven by the cellular CRE motif or the HTLV-1 proximal Tax-responsive element, confirming that CREB-2 and CHOP can interact with each other in vivo. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：57 / 62

页数：6

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