Visfatin Levels in Nonalcoholic Fatty Liver Disease

被引：32

作者：

Akbal, Erdem ^{[1
]}

Kocak, Erdem ^{[1
]}

Tas, Adnan ^{[1
]}

Yuksel, Enver ^{[2
]}

Koklu, Seyfettin ^{[1
]}

机构：

[1] Ankara Educ & Res Hosp, Dept Gastroenterol, TR-06340 Ankara, Turkey

[2] Ankara Educ & Res Hosp, Dept Internal Med, TR-06340 Ankara, Turkey

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2012年 / 26卷 / 02期

关键词：

visfatin; nonalcoholic fatty liver disease; MORBIDLY OBESE-PATIENTS; BARIATRIC SURGERY; VISCERAL FAT; STEATOHEPATITIS; INFLAMMATION; ADIPOKINES; FIBROSIS; PLASMA; NAFLD;

D O I：

10.1002/jcla.21491

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Purpose: Recently, role of adipokin in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has been suggested. Among adipokins, role of leptin and adiponectin is rather well known; however, there are only a few data concerning visfatin. Material and Methods: NAFLD is confirmed in 30 patients by ultrasonography. As a control group, patients without fatty liver or other liver diseases were included. Viral hepatitis, metabolic liver diseases, and autoimmune hepatitis and consumption of alcohol were excluded in all patients. Fasting serum level of visfatin was determined by ELISA method. Results: Serum visfatin concentration in the NAFLD group (14.7 +/- 8.1 ng/ml) was significantly higher than in controls (9.4 +/- 1.6 ng/ml) (P < 0.001). There were no correlations between visfatin and anthropometric parameters, transaminases, lipids, and homeostasis model assessment-estimated insulin resistance (HOMA-IR). Conclusion: Serum visfatin concentration increases in patients with NAFLD. J. Clin. Lab. Anal. 26:115119, 2012. (C) 2012 Wiley Periodicals, Inc.

引用

页码：115 / 119

页数：5

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