Sleep and Synaptic Homeostasis: Structural Evidence in Drosophila

被引：259

作者：

Bushey, Daniel ^{[1
]}

Tononi, Giulio ^{[1
]}

Cirelli, Chiara ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA

来源：

SCIENCE | 2011年 / 332卷 / 6037期

基金：

加拿大健康研究院;

关键词：

MENTAL-RETARDATION PROTEIN; MUSHROOM BODIES; DENDRITIC SPINES; CIRCADIAN CLOCK; PLASTICITY; INCREASES; NEURONS; NEED; WAKE; MICROSCOPY;

D O I：

10.1126/science.1202839

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary for synaptic renormalization. We found that, in three Drosophila neuronal circuits, synapse size or number increases after a few hours of wake and decreases only if flies are allowed to sleep. A richer wake experience resulted in both larger synaptic growth and greater sleep need. Finally, we demonstrate that the gene Fmr1 (fragile X mental retardation 1) plays an important role in sleep-dependent synaptic renormalization.

引用

页码：1576 / 1581

页数：6

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