Immunological response to the Brucella abortus GroEL homolog

被引：27

作者：

Lin, JS ^{[1
]}

Adams, LG ^{[1
]}

Ficht, TA ^{[1
]}

机构：

[1] TEXAS A&M UNIV, COLL VET MED, DEPT VET PATHOBIOL, COLLEGE STN, TX 77843 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 10期

关键词：

D O I：

10.1128/IAI.64.10.4396-4400.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection against a challenge with virulent organisms. The humoral immune response to BaGroEL was restricted to a region of the mature protein which mapped to amino acids 317 to 355 and may represent a useful diagnostic tool for monitoring exposure to B. abortus. Immunity to a challenge with virulent B. abortus S2308 was not observed in the BaGroEL vaccinated mouse model.

引用

页码：4396 / 4400

页数：5

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