Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

被引：317

作者：

Key, T. J. ^{[1
]}

Appleby, P. N. ^{[1
]}

Reeves, G. K. ^{[1
]}

Roddam, A. W. ^{[1
]}

Helzlsouer, K. J. ^{[2
,3
]}

Alberg, A. J. ^{[2
,4
]}

Rollison, D. E. ^{[5
]}

Dorgan, J. F. ^{[6
,7
]}

Brinton, L. A.

Overvad, K. ^{[8
]}

Kaaks, R. ^{[9
]}

Trichopoulou, A. ^{[10
,11
]}

Clavel-Chapelon, F. ^{[12
,13
]}

Panico, S. ^{[14
]}

Duell, E. J. ^{[15
]}

Peeters, P. H. M. ^{[16
,17
]}

Rinaldi, S. ^{[18
]}

Riboli, E. ^{[17
]}

Fentiman, I. S. ^{[19
,20
]}

Dowsett, M.

Manjer, J. ^{[21
]}

Lenner, P. ^{[22
]}

Hallmans, G. ^{[23
]}

Baglietto, L. ^{[24
]}

English, D. R. ^{[24
]}

Giles, G. G. ^{[24
]}

Hopper, J. L. ^{[24
]}

Severi, G. ^{[24
]}

Morris, H. A.

Koenig, K. ^{[25
]}

Zeleniuch-Jacquotte, A. ^{[25
]}

Arslan, A. A.

Toniolo, P. ^{[26
]}

Shore, R. E. ^{[27
]}

Krogh, V. ^{[28
]}

Micheli, A. ^{[28
]}

Berrino, F. ^{[28
]}

Muti, P. ^{[29
]}

Barrett-Connor, E. ^{[30
]}

Laughlin, G. A. ^{[30
]}

Kabuto, M. ^{[31
]}

Akiba, S. ^{[32
]}

Stevens, R. G. ^{[33
]}

Neriishi, K. ^{[34
]}

Land, C. E. ^{[35
]}

Cauley, J. A. ^{[36
]}

Lui, Li Yung ^{[37
,38
]}

Cummings, Steven R. ^{[37
,38
]}

Gunter, M. J. ^{[39
]}

Rohan, T. E. ^{[39
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[4] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA

[5] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Interdisciplinary Oncol, Tampa, FL 33682 USA

[6] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[7] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[8] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark

[9] DKFZ, Heidelberg, Germany

[10] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[11] Hellen Hlth Fdn, Athens, Greece

[12] INSERM, Ctr Res Epidemiol & Populat, U1018, Villejuif, France

[13] Paris S Univ, UMRS1018, IGR, Villejuif, France

[14] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[15] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain

[16] Univ Med Ctr, Julius Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[17] Univ London Imperial Coll Sci Technol & Med, London, England

[18] Int Agcy Res Canc, F-69372 Lyon, France

[19] Guys Hosp, London SE1 9RT, England

[20] Inst Canc Res, Dept Biochem, London SW3 6JB, England

[21] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[22] Umea Univ, Dept Radiat Sci, Umea, Sweden

[23] Umea Univ Hosp, Dept Clin Med & Publ Hlth, Umea, Sweden

[24] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[25] NYU, Sch Med, Dept Environm Med, New York, NY USA

[26] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA

[27] Radiat Effects Res Fdn, Hiroshima, Japan

[28] Fdn Ist Nazl Tumori, Milan, Italy

[29] Ist Nazl Tumori Regina Elena, Rome, Italy

[30] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA

[31] Natl Inst Environm Studies, Environm Risk Res Div, Ibaraki, Japan

[32] Kagoshima Univ, Fac Med, Dept Publ Hlth, Kagoshima 890, Japan

[33] Univ Connecticut, Ctr Hlth, Dept Community Med, Farmington, CT USA

[34] Radiat Effects Res Fdn, Dept Clin Studies, Hiroshima, Japan

[35] NCI, Radiat Epidemiol Branch, Bethesda, MD 20892 USA

[36] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15260 USA

[37] Calif Pacific Med Ctr, San Francisco Coordinating Ctr, San Francisco, CA USA

[38] San Francisco Coordinating Ctr, Study Osteoporot Fractures Res Grp, San Francisco, CA USA

[39] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 105卷 / 05期

关键词：

breast cancer; hormones; oestrogens; androgens; sex hormone-binding globulin; LIFE-STYLE FACTORS; GROWTH-FACTOR-I; DEHYDROEPIANDROSTERONE-SULFATE; CIGARETTE-SMOKING; ESTRADIOL LEVELS; SERUM CONCENTRATIONS; ADRENAL ANDROGENS; BINDING GLOBULIN; STEROID-HORMONES; FAT DISTRIBUTION;

D O I：

10.1038/bjc.2011.254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK

引用

页码：709 / 722

页数：14

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