Adhesion events in angiogenesis

被引:258
作者
Eliceiri, BP [1 ]
Cheresh, DA [1 ]
机构
[1] Scripps Res Inst, La Jolla, CA 92037 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0955-0674(00)00252-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Recent work from several laboratories indicates that the coordination of endothelial cell adhesion events with growth factor receptor inputs regulates endothelial cell responses during angiogenesis. Analyses of the signaling pathways downstream of integrins, cadherins and growth-factor receptors are providing an insight into the molecular basis of known anti-angiogenic strategies, as well as into the design of novel therapies.
引用
收藏
页码:563 / 568
页数:6
相关论文
共 68 条
[1]
Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-Flip and implications for anoikis [J].
Aoudjit, F ;
Vuori, K .
JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :633-643
[2]
Aplin AE, 1998, PHARMACOL REV, V50, P197
[3]
A molecular mechanism of integrin crosstalk:: αvβ3 suppression of calcium/calmodulin-dependent protein kinase II regulates α5β1 function [J].
Blystone, SD ;
Slater, SE ;
Williams, MP ;
Crow, MT ;
Brown, EJ .
JOURNAL OF CELL BIOLOGY, 1999, 145 (04) :889-897
[4]
INTEGRIN ALPHA(V)BETA(3) DIFFERENTIALLY REGULATES ADHESIVE AND PHAGOCYTIC FUNCTIONS OF THE FIBRONECTIN RECEPTOR ALPHA(5)BETA(1) [J].
BLYSTONE, SD ;
GRAHAM, IL ;
LINDBERG, FP ;
BROWN, EJ .
JOURNAL OF CELL BIOLOGY, 1994, 127 (04) :1129-1137
[5]
Platelet-derived growth factor receptor β and vascular endothelial growth factor receptor 2 bind to the β3 integrin through its extracellular domain [J].
Borges, E ;
Jan, YW ;
Ruoslahti, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (51) :39867-39873
[6]
INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].
BROOKS, PC ;
MONTGOMERY, AMP ;
ROSENFELD, M ;
REISFELD, RA ;
HU, TH ;
KLIER, G ;
CHERESH, DA .
CELL, 1994, 79 (07) :1157-1164
[7]
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 [J].
Brooks, PC ;
Stromblad, S ;
Sanders, LC ;
vonSchalscha, TL ;
Aimes, RT ;
StetlerStevenson, WG ;
Quigley, JP ;
Cheresh, DA .
CELL, 1996, 85 (05) :683-693
[8]
A mechanism for modulation of cellular responses to VEGF: Activation of the integrins [J].
Byzova, TV ;
Goldman, CK ;
Pampori, N ;
Thomas, KA ;
Bett, A ;
Shattil, SJ ;
Plow, EF .
MOLECULAR CELL, 2000, 6 (04) :851-860
[9]
Carmeliet P, 2000, ANN NY ACAD SCI, V902, P249
[10]
Endogenous regulators of angiogenesis - emphasis on proteins with thrombospondin - type I motifs [J].
Carpizo, D ;
Iruela-Arispe, ML .
CANCER AND METASTASIS REVIEWS, 2000, 19 (1-2) :159-165