Ubiquitylation of ion channels

被引:84
作者
Abriel, H [1 ]
Staub, O
机构
[1] Univ Lausanne, Dept Pharmacol & Toxicol, Lausanne, Switzerland
[2] Univ Lausanne, Serv Cardiol, Lausanne, Switzerland
关键词
D O I
10.1152/physiol.00033.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.
引用
收藏
页码:398 / 407
页数:10
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