Ubiquitylation of ion channels

被引：85

作者：

Abriel, H ^{[1
]}

Staub, O

机构：

[1] Univ Lausanne, Dept Pharmacol & Toxicol, Lausanne, Switzerland

[2] Univ Lausanne, Serv Cardiol, Lausanne, Switzerland

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00033.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.

引用

页码：398 / 407

页数：10

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