Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation: A meta-analysis

被引：69

作者：

Hsu, Wan-Yu ^{[1
,6
,7
]}

Cheng, Chia-Hsiung ^{[1
,6
,7
]}

Lin, Ming-Wei ^{[4
,8
]}

Shih, Yang-Hsin ^{[2
,9
]}

Liao, Kwong-Kum ^{[2
,9
]}

Lin, Yung-Yang ^{[1
,2
,3
,5
,6
,7
,9
]}

机构：

[1] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Dept Neurol, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan

[5] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[6] Taipei Vet Gen Hosp, Neurophysiol Lab, Taipei 112, Taiwan

[7] Taipei Vet Gen Hosp, Integrated Brain Res Lab, Taipei 112, Taiwan

[8] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 112, Taiwan

[9] Taipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan

来源：

EPILEPSY RESEARCH | 2011年 / 96卷 / 03期

关键词：

Meta-analysis; Epilepsy; Repetitive transcranial magnetic stimulation (rTMS); Low frequency; Antiepileptic effect; CORTICAL EXCITABILITY; LOBE EPILEPSY; MOTOR CORTEX; EEG; TMS; ACTIVATION; DECREASES; SEIZURES; QUALITY; PATIENT;

D O I：

10.1016/j.eplepsyres.2011.06.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Purpose: To evaluate the antiepileptic efficacy of low frequency repetitive transcranial magnetic stimulation (rTMS) in medically intractable epilepsy. Methods: A comprehensive literature search was performed on articles published from 1990 to 2010 in Medline, Pubmed, CINAHL, and Cochrane using the following keywords: epilepsy, seizure, transcranial magnetic stimulation, repetitive transcranial magnetic stimulation. Two reviewers assessed article eligibility and extracted the data independently. For outcome measures, effect size and 95% confidence interval (CI) were calculated for seizure frequency, spike number, duration of epileptiform abnormalities (EAs), and resting motor threshold (RMT) by using fixed and random effect models. Results: Eleven articles were identified, with a total of 164 participants. Based on seizure frequency, a significant effect size was found (effect size: 0.34, with a 95% CI at 0.10-0.57). Considering between-study heterogeneity, we conducted a second meta-analysis, and the underlying etiology was considered important for the treatment effect. Cortical dysplasia or neocortical epilepsy showed an effect size of 0.71, with a 95% CI at 0.30-1.12. In contrast, other epileptic disorders showed an effect size of 0.22. Conclusion: Low frequency rTMS has a favorable effect on seizure reduction, particularly evident in patients with neocortical epilepsy or cortical dysplasia. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：231 / 240

页数：10

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