An efficient synthesis of tetrasubstituted imidazoles from N-(2-oxo)-amides

被引：110

作者：

Claiborne, CF ^{[1
]}

Liverton, NJ ^{[1
]}

Nguyen, KT ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(98)02058-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-(2-Oxo)-amides were efficiently converted to tri- and tetra- substituted imidazoles under neutral reaction conditions upon treatment with neat ammonium trifluoroacetate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8939 / 8942

页数：4

共 6 条

[1] ALPER H, 1982, J ORG CHEM, V47, P3595
[2] BECCALLI E, 1980, CHEM LETT, P657
[3] UNTERSUCHUNGEN IN DER AZOLREIHE .5. UMSETZUNGEN DER OXAZOLONE-(2) MIT METALLORGANISCHEN VERBINDUNGEN
GOMPPER, R
[J]. CHEMISCHE BERICHTE-RECUEIL, 1957, 90 (03): : 374 - 382
[4] Grimmett M., 1970, Adv. Heterocycl. Chem, V12, P103, DOI [10.1016/S0065-2725(08)60973-3, DOI 10.1016/S0065-2725(08)60973-3]
[5] A PROTEIN-KINASE INVOLVED IN THE REGULATION OF INFLAMMATORY CYTOKINE BIOSYNTHESIS
LEE, JC
LAYDON, JT
MCDONNELL, PC
GALLAGHER, TF
KUMAR, S
GREEN, D
MCNULTY, D
BLUMENTHAL, MJ
HEYS, JR
LANDVATTER, SW
STRICKLER, JE
MCLAUGHLIN, MM
SIEMENS, IR
FISHER, SM
LIVI, GP
WHITE, JR
ADAMS, JL
YOUNG, PR
[J]. NATURE, 1994, 372 (6508) : 739 - 746
[6] LEE JC, 1995, CIRC SHOCK, V44, P97

← 1 →